Pyridine → N-[2-Fluoro-5-(5-methoxypyridin-3-ylethynyl)-phenyl]-methanesulfonamide

Reaction equation

[CH3:25][S:26]([Cl:27])(=[O:28])=[O:29].[Cl:30][CH2:31][Cl:32].[F:1][c:2]1[c:3]([NH2:18])[cH:4][c:5]([C:8]#[C:9][c:10]2[cH:11][n:12][cH:13][c:14]([O:16][CH3:17])[cH:15]2)[cH:6][cH:7]1.[cH:19]1[cH:20][cH:21][n:22][cH:23][cH:24]1>>[F:1][c:2]1[c:3]([NH:18][S:26]([CH3:25])(=[O:28])=[O:29])[cH:4][c:5]([C:8]#[C:9][c:10]2[cH:11][n:12][cH:13][c:14]([O:16][CH3:17])[cH:15]2)[cH:6][cH:7]1

Participants

Reactant 4

HCID 1049Pyridine

HCID 6344Dichloromethane

HCID 31297Methanesulfonyl chloride

HCID 67047543HCID 67047543, compound

Product 1

HCID 67047716N-[2-Fluoro-5-(5-methoxypyridin-3-ylethynyl)-phenyl]-methanesulfonamide

Sources & evidence

ORD record: ord-40617e87e9734f36baf72246db0c6bfa
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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