Dimethyl Sulfate → 7-Methoxy-2-naphthol

HRID 883597

Reaction equation

HRID 883597 reaction equation
[OH-].[Na+].S([O:8][CH3:9])(OC)(=O)=O.[OH:10][C:11]1[CH:20]=[CH:19][C:18]2[C:13](=[CH:14][C:15](O)=[CH:16][CH:17]=2)[CH:12]=1>ClCCl.O>[OH:10][C:11]1[CH:20]=[CH:19][C:18]2[C:13](=[CH:14][C:15]([O:8][CH3:9])=[CH:16][CH:17]=2)[CH:12]=1

Participants

6

Reactant 3

HCID 6497Dimethyl Sulfate2×HCID 113972,7-NaphthalenediolHCID 14798Sodium Hydroxide2×

Product 1

HCID 8531737-Methoxy-2-naphtholYield 30.1%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6344DichloromethaneSolvent

Procedure

Sodium hydroxide (20 ml, 1M) and dimethyl sulfate (15.0 ml, 158 mmol) were added dropwise to a solution of 2,7-dihydroxynaphthalene (6.6 g, 40 mmol) in dichloromethane (100 ml) and water (60 ml). Additional sodium hydroxide (20 ml, 1M) and dimethyl sulfate (15.0 ml, 158 mmol) were added and the resulting mixture was stirred at room temperature for 2 hours. The two phases were separated and the aqueous layer was extracted with dichloromethane twice. The combined organic extracts were washed with 1 M HCl, dried over magnesium sulfate and concentrated under vacuum. The crude material was purified by column chromatography (5:1 heptane/ethyl acetate) to give 2-hydroxy-7-methoxynaphthalene (2.1 g, 30%, 100% AUC HPLC): 1H NMR (300 MHz, CDCl3) δ 7.66-7.70 (m, 2H), 6.94-7.08 (m, 4H), 4.90 (s, 1H), 3.92 (s, 3H).

Workup

  1. customThe two phases were separated
  2. extractionthe aqueous layer was extracted with dichloromethane twice
  3. washThe combined organic extracts were washed with 1 M HCl
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated under vacuum
  6. customThe crude material was purified by column chromatography (5:1 heptane/ethyl acetate)

Sources & evidence

ORD record
ord-c4540ba3fa7444ad99a0695efb7ce8df
Source dataset
uspto-grants-2012_08
Patent number
US08236796B2

Linked notes

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