Ethanol → Ethyl 2-(3-hydroxy-4-methoxyphenyl)acetate

HRID 885270

Reaction equation

HRID 885270 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].S(=O)(=O)(O)O.[CH3:19][CH2:20]O>>[CH2:19]([O:12][C:11](=[O:13])[CH2:10][C:4]1[CH:5]=[CH:6][C:7]([O:8][CH3:9])=[C:2]([OH:1])[CH:3]=1)[CH3:20]

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 1605623-Hydroxy-4-methoxybenzeneacetic acid

Product 1

HCID 5324706Ethyl 2-(3-hydroxy-4-methoxyphenyl)acetate

Procedure

To 3-hydroxy-4-methoxyphenylacetic acid (5.0 g, 23.8 mmol) in EtOH (100 mL) was added sulfuric acid (1 mL), and the reaction was stirred overnight at room temperature. Once no starting material was seen by analytical tlc, the mixture was concentrated to give the desired product.

Workup

  1. concentrationthe mixture was concentrated

Sources & evidence

ORD record
ord-8e44c9051365405ca7c7ab4f06655442
Source dataset
uspto-grants-2012_08
Patent number
US08242145B2

Linked notes

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