Benzyl Alcohol → (3-Benzyloxy-4-chloro-phenyl)-acetic acid

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][C:3]=1F.[CH2:13]([OH:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH2:13]([O:20][C:3]1[CH:4]=[C:5]([CH2:8][C:9]([OH:11])=[O:10])[CH:6]=[CH:7][C:2]=1[Cl:1])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

Reactant 2

HCID 244Benzyl Alcohol

HCID 38149542-(4-Chloro-3-fluorophenyl)acetic acid

Product 1

HCID 58149177(3-Benzyloxy-4-chloro-phenyl)-acetic acid

Procedure

Prepared according to the procedure described in Example 24, Step 1, using the following starting materials: 4-chloro-3-fluorophenylacetic acid and benzyl alcohol.

Workup

customPrepared

Sources & evidence

ORD record: ord-356331d407504a0e8f5e6bd037fc2345
Source dataset: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08242145B2

Reaction notes

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