5-Bromo-2-fluorobenzaldehyde → [3-(4-Bromo-2-formyl-phenoxy)-4-methoxy-phenyl]acetic acid methyl ester
Reaction equation
[CH3:1][O:2][C:3](=[O:14])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[C:7]([OH:13])[CH:6]=1.[Br:15][C:16]1[CH:17]=[CH:18][C:19](F)=[C:20]([CH:23]=1)[CH:21]=[O:22]>>[CH3:1][O:2][C:3](=[O:14])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[C:7]([O:13][C:19]2[CH:18]=[CH:17][C:16]([Br:15])=[CH:23][C:20]=2[CH:21]=[O:22])[CH:6]=1Participants
3
Procedure
Prepared according to the procedure described in Example 6, Step 2, using the following starting materials: (3-hydroxy-4-methoxy-phenyl)-acetic acid methyl ester and 5-bromo-2-fluorobenzaldehyde.
Workup
- customPrepared
Sources & evidence
- ORD record
- ord-111e5225ca4f4f7c9b1f572e6d748d20
- Source dataset
- uspto-grants-2012_08