(1S)-2-amino-1-phenylethan-1-ol → (3-{4-Bromo-2-[((S)-2-hydroxy-2-phenyl-ethylamino)-methyl]-phenoxy}-phenyl)-acetic acid methyl ester

HRID 885336

Reaction equation

HRID 885336 reaction equation
[CH3:1][O:2][C:3](=[O:21])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][C:13]=2[CH:19]=O)[CH:6]=1.[NH2:22][CH2:23][C@H:24]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[OH:25]>>[CH3:1][O:2][C:3](=[O:21])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][C:13]=2[CH2:19][NH:22][CH2:23][C@@H:24]([OH:25])[C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH:6]=1

Participants

3

Reactant 2

HCID 643217(1S)-2-amino-1-phenylethan-1-olHCID 58237467[3-(4-Bromo-2-formyl-phenoxy)-phenyl]-acetic acid methyl ester

Product 1

HCID 58237603(3-{4-Bromo-2-[((S)-2-hydroxy-2-phenyl-ethylamino)-methyl]-phenoxy}-phenyl)-acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 45, Step 3, using the following starting materials: [3-(4-bromo-2-formyl-phenoxy)-phenyl]-acetic acid methyl ester and (S)-(+)-2-amino-1-phenylethanol.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-8a7a0ea4a1964e90af28b3a18c071208
Source dataset
uspto-grants-2012_08
Patent number
US08242145B2

Linked notes

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