2,2-Difluoro-4-phenylbutan-1-ol → 2,2-Difluoro-2-(3-methoxyphenyl)ethan-1-ol

Reaction equation

[F:1][C:2]([F:16])([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[CH:9]=1)[C:3](OCC)=[O:4].FC(F)(CCC1C=CC=CC=1)CO>>[F:1][C:2]([F:16])([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[CH:9]=1)[CH2:3][OH:4]

Participants

Reactant 2

HCID 184257752,2-Difluoro-4-phenylbutan-1-ol

HCID 39058305Ethyl Difluoro-(3-methoxyphenyl)acetate

Product 1

HCID 672447182,2-Difluoro-2-(3-methoxyphenyl)ethan-1-ol

Procedure

Obtained from Intermediate 67 (4.35 g, 19 mmol) by the procedure described in Intermediate 2. The title compound was obtained (3.19 g, 90%) as oil.

Sources & evidence

ORD record: ord-ff86116b55354dc48792f2ddb0053355
Source dataset: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08242177B2

Reaction notes

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