1-Bromo-2-methylpropane → 2-Chloro-4-(1-isobutyl-2-methyl-1H-imidazol-4-ylethynyl)-pyridine

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:15])[NH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=1.Br[CH2:17][CH:18]([CH3:20])[CH3:19]>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:15])[N:13]([CH2:17][CH:18]([CH3:20])[CH3:19])[CH:14]=2)[CH:5]=[CH:4][N:3]=1

Participants

Reactant 2

HCID 65551-Bromo-2-methylpropane

HCID 178418879HCID 178418879, compound

Product 1

HCID 865958952-Chloro-4-(1-isobutyl-2-methyl-1H-imidazol-4-ylethynyl)-pyridine

Procedure

The title compound, MS: m/e=274.1 (M+H+), was prepared in accordance with the general method of example 1 from 2-chloro-4-(2-methyl-1H-imidazol-4-ylethynyl)-pyridine and 1-bromo-2-methylpropane.

Sources & evidence

ORD record: ord-d0dfd97f4acb491a8e42db7257f82860
Source dataset: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07091222B2

Reaction notes

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