Acetic Anhydride → N-(Isoquinolin-3-yl)acetamide

Reaction equation

[NH2:1][C:2]1[N:3]=[CH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[CH3:12][C:13](OC(C)=O)=[O:14]>>[CH:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:11]=[C:2]([NH:1][C:13](=[O:14])[CH3:12])[N:3]=1

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 311869Isoquinolin-3-Amine

Product 1

HCID 12366594N-(Isoquinolin-3-yl)acetamide

Procedure

3-Aminoisoquinoline (495 mg, 3.44 mmol) was stirred in Ac2O (9 mL) at 60° for 16 hours. The mixture was cooled to room temperature and concentrated in vacuo to provide the title compound which was used in the next step without further purification.

Workup

concentrationconcentrated in vacuo

Sources & evidence

ORD record: ord-fc92afb6bdd2453ab5fb523762a690c5
Source dataset: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08247413B2

Reaction notes

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