2-Bromo-1,1-difluoroethane → 4-[1-(2,2-Difluoro-ethyl)-2-methyl-1H-imidazol-4-ylethynyl]-2-methyl-pyridine

HRID 8880

Reaction equation

HRID 8880 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:15])[NH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=1.Br[CH2:17][CH:18]([F:20])[F:19]>>[F:19][CH:18]([F:20])[CH2:17][N:13]1[CH:14]=[C:10]([C:9]#[C:8][C:6]2[CH:5]=[CH:4][N:3]=[C:2]([CH3:1])[CH:7]=2)[N:11]=[C:12]1[CH3:15]

Participants

3

Reactant 2

HCID 1361862-Bromo-1,1-difluoroethaneHCID 178418884HCID 178418884, compound

Product 1

HCID 111962774-[1-(2,2-Difluoro-ethyl)-2-methyl-1H-imidazol-4-ylethynyl]-2-methyl-pyridine

Procedure

The title compound, MS: m/e=262.1 (M+H+), was prepared in accordance with the general method of example 1 from 2-methyl-4-(2-methyl-1H-imidazol-4-ylethynyl)-pyridine and 2-bromo-1,1-difluoro ethane.

Sources & evidence

ORD record
ord-3ee0bb3ddc264ecaac4ee315d3cd79dd
Source dataset
uspto-grants-2006_08
Patent number
US07091222B2

Linked notes

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