5-Bromo-2,3-dihydro-1-benzofuran → HCID 11651447, compound

HRID 888194

Reaction equation

HRID 888194 reaction equation
CO[C:3]1[CH:4]=[C:5]([N:11]2[CH2:16][CH2:15][NH:14][C@H:13]([CH3:17])[CH2:12]2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].Br[C:19]1C=CC2OCCC=2C=1>>[O:9]1[C:8]2[CH:7]=[CH:6][C:5]([N:11]3[CH2:16][CH2:15][NH:14][C@H:13]([CH3:17])[CH2:12]3)=[CH:4][C:3]=2[CH2:19][CH2:10]1

Participants

3

Reactant 2

HCID 27761595-Bromo-2,3-dihydro-1-benzofuranHCID 58487959HCID 58487959, compound

Product 1

HCID 11651447HCID 11651447, compound

Procedure

The title compound was prepared following the procedure of Intermediate 25, but starting from 5-bromo-2,3-dihydrobenzo[b]furan. Purification by flash chromatography (CHCl3/MeOH) gave the title compound as a brown oil. M+(ESI): 219.2. HPLC (Condition A), Rt: 1.3 min (HPLC purity: 99.9%).

Workup

  1. customThe title compound was prepared
  2. customPurification by flash chromatography (CHCl3/MeOH)

Sources & evidence

ORD record
ord-c5f72056f07d470da389ea08d9d675b5
Source dataset
uspto-grants-2012_08
Patent number
US08247437B2

Linked notes

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