2-Chloro-4-(2-(trimethylsilyl)ethynyl)pyridine → 2-Chloro-4-[1-(2,2-difluoro-ethyl)-2-methyl-1H-imidazol-4-ylethynyl]-pyridine

HRID 8882

Reaction equation

HRID 8882 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][Si](C)(C)C)[CH:5]=[CH:4][N:3]=1.[F:14][CH:15]([F:24])[CH2:16][N:17]1[CH:21]=[C:20](I)[N:19]=[C:18]1[CH3:23]>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][C:20]2[N:19]=[C:18]([CH3:23])[N:17]([CH2:16][CH:15]([F:24])[F:14])[CH:21]=2)[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 219853912-Chloro-4-(2-(trimethylsilyl)ethynyl)pyridineHCID 219853931H-Imidazole, 1-(2,2-difluoroethyl)-4-iodo-2-methyl-

Product 1

HCID 112890312-Chloro-4-[1-(2,2-difluoro-ethyl)-2-methyl-1H-imidazol-4-ylethynyl]-pyridine

Procedure

The title compound, MS: m/e=282.0 (M+H+), was prepared in accordance with the general method of example A, step 2, from 2-chloro-4-trimethylsilanylethynyl-pyridine and 1-(2,2-difluoro-ethyl)-4-iodo-2-methyl-1H-imidazole.

Sources & evidence

ORD record
ord-f3776236429f4aeb87a7c0b85091fbfc
Source dataset
uspto-grants-2006_08
Patent number
US07091222B2

Linked notes

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