3-(4-Aminophenyl)-1,4-dimethylpiperazin-2-one → (R)-5-bromo-3-(4-(1,4-dimethyl-3-oxopiperazin-2-yl)phenylamino)-1-methylpyrazin-2(1H)-one

HRID 888438

Reaction equation

HRID 888438 reaction equation
[Br:1][C:2]1[N:3]=[C:4]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([CH:17]3[C:22](=[O:23])[N:21]([CH3:24])[CH2:20][CH2:19][N:18]3[CH3:25])=[CH:13][CH:12]=2)[C:5](=[O:9])[N:6]([CH3:8])[CH:7]=1.CN1CCN(C)C(C2C=CC(N)=CC=2)C1=O>>[Br:1][C:2]1[N:3]=[C:4]([NH:10][C:11]2[CH:12]=[CH:13][C:14]([C@@H:17]3[C:22](=[O:23])[N:21]([CH3:24])[CH2:20][CH2:19][N:18]3[CH3:25])=[CH:15][CH:16]=2)[C:5](=[O:9])[N:6]([CH3:8])[CH:7]=1

Participants

3

Reactant 2

HCID 576251203-(4-Aminophenyl)-1,4-dimethylpiperazin-2-oneHCID 576251295-Bromo-3-(4-(1,4-dimethyl-3-oxopiperazin-2-yl)phenylamino)-1-methylpyrazin-2(1H)-one

Product 1

HCID 57625140(R)-5-bromo-3-(4-(1,4-dimethyl-3-oxopiperazin-2-yl)phenylamino)-1-methylpyrazin-2(1H)-one

Procedure

The (R)-isomer of compound 14 can be prepared from the (+)-isomer of 1,4-dimethyl-3-(4-aminophenyl)piperazin-2-one using the same procedure.

Sources & evidence

ORD record
ord-b97052fd6ca2400da328ddae45a489af
Source dataset
uspto-grants-2012_08
Patent number
US08247550B2

Linked notes

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