Hydrazinecarboxylic acid, ethyl ester → HCID 178473566, compound

HRID 889162Notes

Reaction equation

HRID 889162 reaction equation
[C:1]([O:5][CH2:6][CH3:7])(=[O:4])[NH:2][NH2:3].CS[C:10]1[S:11][CH2:12][CH2:13][N:14]=1>C(O)C>[CH2:6]([O:5][C:1]([NH:2][N:3]=[C:10]1[NH:14][CH2:13][CH2:12][S:11]1)=[O:4])[CH3:7]

Participants

4

Reactant 2

HCID 20064Hydrazinecarboxylic acid, ethyl esterHCID 883244,5-Dihydro-2-(methylthio)thiazole

Product 1

HCID 178473566HCID 178473566, compoundYield 25.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of ethyl carbazate (23.4 g), 2-(methylthio)-2-thiazoline (25 g) and ethanol (250 ml) was heated to reflux for 3 days. It was then stirred at room temperature for 2 days. The precipitate was collected by filtration and washed with ethanol to obtain the title compound (9.05 g).

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 3 days
  3. filtrationThe precipitate was collected by filtration
  4. washwashed with ethanol

Sources & evidence

ORD record
ord-9e029b7850754c5e9764887691467095
Source dataset
uspto-grants-2012_08
Patent number
US08252810B2

Reaction notes

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