Ethionamide → HCID 22249370, compound
Reaction equation
[CH3:1][CH2:2][C:3]1[CH:8]=[C:7]([C:9]([NH2:11])=S)[CH:6]=[CH:5][N:4]=1>CO.[Ni]>[CH2:2]([C:3]1[CH:8]=[C:7]([CH2:9][NH2:11])[CH:6]=[CH:5][N:4]=1)[CH3:1]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
To a solution of 2-ethyl-4-thiopyridylamide (10 g) in MeOH (250 ml) was added Raney 2800 Nickel (5 g, Aldrich) in one portion. The mixture was stirred at RT for 2 days then at 60° C. for 16 h. The mixture was filtered, concentrated to provide the desired compound.
Workup
- waitat 60° C. for 16 h
- filtrationThe mixture was filtered
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-7ce83bccd8ed4d75861a135792b968eb
- Source dataset
- uspto-grants-2006_02
- Patent number
- US06995162B2
Reaction notes
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