Ammonia → HCID 10118077, compound

HRID 891301

Reaction equation

HRID 891301 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9](=[O:24])[NH:10][N:11]=[CH:12][C:13]=2[C:14]2[CH:19]=[CH:18][C:17]([S:20]([CH3:23])(=[O:22])=[O:21])=[CH:16][CH:15]=2)=[CH:4][CH:3]=1.I[C:26]1[CH:27]=[C:28]([C:32]([F:35])([F:34])[F:33])[CH:29]=[CH:30][CH:31]=1.N>>[F:33][C:32]([F:35])([F:34])[C:28]1[CH:27]=[C:26]([N:10]2[C:9](=[O:24])[C:8]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)=[C:13]([C:14]3[CH:19]=[CH:18][C:17]([S:20]([CH3:23])(=[O:22])=[O:21])=[CH:16][CH:15]=3)[CH:12]=[N:11]2)[CH:31]=[CH:30][CH:29]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 67868Benzene, 1-iodo-3-(trifluoromethyl)-HCID 219341294-(4-chlorophenyl)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone

Product 1

HCID 10118077HCID 10118077, compound

Procedure

The title compound was prepared according to Example 93, starting with 4-(4-chlorophenyl)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone in place of 4-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone and substituting 3-iodobenzotrifluoride in place of 4-bromothioanisole (yield: 210 mg, 59.5%). mp 103-105° C. 1H NMR (300 MHz, CDCl3) δ 3.08 (s, 3H), 7.18 (d, J=9 Hz, 2H), 7.28 (d, J=9 Hz, 2H), 7.41 (d, J=9 Hz, 2H), 7.65 (m, 2H), 7.95 (m, 3H), 8.04 (m, 2H). MS (DCI/NH3) m/z 505 (M+H)+, 525 (M+NH4)+. Anal. calc. for C24H16ClF3N2O3S: C, 57.14; H, 3.17; N, 5.56. Found: C, 56.61; H, 3.28; N, 5.38.

Sources & evidence

ORD record
ord-52800ce513a24cd5a3378f97747f4804
Source dataset
uspto-grants-2006_02
Patent number
US07001895B2

Linked notes

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