Dichloromethane → 1-[2-(2,4-Difluorophenyl)-2-fluoroethyl]-3-{[(4-fluorophenyl)sulfonyl]methyl}azetidine

HRID 89136

Reaction equation

HRID 89136 reaction equation
[CH2:27]([N:28]([S:29]([F:30])([F:31])[F:33])[CH2:32][CH3:34])[CH3:35].[Cl:36][CH2:37][Cl:38].[F:1][c:2]1[c:3]([CH:9]([CH2:10][N:11]2[CH2:12][CH:13]([CH2:15][S:16](=[O:17])(=[O:18])[c:19]3[cH:20][cH:21][c:22]([F:25])[cH:23][cH:24]3)[CH2:14]2)[OH:26])[cH:4][cH:5][c:6]([F:8])[cH:7]1>>[F:1][c:2]1[c:3]([CH:9]([CH2:10][N:11]2[CH2:12][CH:13]([CH2:15][S:16](=[O:17])(=[O:18])[c:19]3[cH:20][cH:21][c:22]([F:25])[cH:23][cH:24]3)[CH2:14]2)[F:33])[cH:4][cH:5][c:6]([F:8])[cH:7]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 123472(Diethylamino)sulfur trifluorideHCID 219783771-(2,4-Difluorophenyl)-2-(3-{[(4-fluorophenyl)sulfonyl]methyl}azetidin-1-yl)ethanol

Product 1

HCID 219783951-[2-(2,4-Difluorophenyl)-2-fluoroethyl]-3-{[(4-fluorophenyl)sulfonyl]methyl}azetidine

Sources & evidence

ORD record
ord-1919ff189a1a4ded86ab996036d933bd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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