L-Tyrosine 1,1-dimethylethyl ester → HCID 178467516, compound

HRID 891978

Reaction equation

HRID 891978 reaction equation
C(O[C:4]1[C:8]([O:9][CH2:10][CH3:11])=[N:7][S:6](=[O:13])(=[O:12])[N:5]=1)C.[C:14]([O:18][C:19](=[O:30])[C@H:20]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=1)[NH2:21])([CH3:17])([CH3:16])[CH3:15]>C(O)C>[C:14]([O:18][C:19](=[O:30])[C@H:20]([CH2:22][C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=1)[NH:21][C:4]1[C:8]([O:9][CH2:10][CH3:11])=[N:7][S:6](=[O:12])(=[O:13])[N:5]=1)([CH3:17])([CH3:15])[CH3:16]

Participants

4

Reactant 2

HCID 6950582L-Tyrosine 1,1-dimethylethyl esterHCID 112179953,4-Diethoxy-1,2,5-thiadiazole-1,1-dioxide

Product 1

HCID 178467516HCID 178467516, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 3,4-diethyloxy-1,1-dioxo-1,2,5-thiadiazole (400 mg, 1.94 mmol) and L-tyrosine t-butyl ester (1.25 g, 5.2 mmol) in ethanol (25 mL) was stirred at room temperature overnight. Solvent was removed under reduced pressure and the product used in further transformations without further purification (Yield 790 mg).

Workup

  1. customSolvent was removed under reduced pressure
  2. customthe product used in further transformations without further purification (Yield 790 mg)

Sources & evidence

ORD record
ord-510eca8d495f492b831bf25dde5ab7f4
Source dataset
uspto-grants-2006_02
Patent number
US07005433B2

Linked notes

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