HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,7-Diphenyl-4-heptanol → 1-(4-tert-Butyldiphenylsilyloxymethylphenyl)-7-phenyl-heptan-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,7-Diphenyl-4-heptanol | HCID 10539870 | — |
| Reactant | 4-(4-tert-Butyldiphenylsilyloxymethyl-phenyl)butyraldehyde | HCID 19694131 | — |
| Reactant | HCID 178418471 | HCID 178418471 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(4-tert-Butyldiphenylsilyloxymethylphenyl)-7-phenyl-heptan-4-ol | HCID 19694136 | 122.9% |
Reaction Steps
The alcohol 173 was prepared from 2.12 g (5.0 mmol) of 172 and 9.0 mL (9 mmol) of 120 in 50 mL of THF as described for the synthesis of 121 in Example 1. Flash chromatography (elution with 10% ethyl acetate in hexane) gave 3.3 g of the alcohol 173. 1H NMR consistent with the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05723459 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-796ad571c9a54fe982b77146ea41a2af |
| Source note | uspto-grants-1998_03 |