Bromine → HCID 15005405, compound
Reaction equation
[Br:1]Br.[O:3]=[C:4]([CH3:14])[CH2:5][C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[CH:8][CH:7]=1>ClCCl>[Br:1][CH:5]([C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[CH:8][CH:7]=1)[C:4](=[O:3])[CH3:14]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Bromine (5.28 g) in dichloromethane (80 ml) was added dropwise at 25° C. over 1 hour to 4-(2-oxopropyl)benzonitrile in dichloromethane (85 ml). The reaction mixture was stirred for 1/2 hour after the addition was complete. The mixture was washed with brine (50 ml), dried over magnesium sulphate and the solvent removed under reduced pressure to yield the title compound as a pale red oil (7.55 g, 96%).
Workup
- additionafter the addition
- washThe mixture was washed with brine (50 ml)
- dry with materialdried over magnesium sulphate
- customthe solvent removed under reduced pressure
Sources & evidence
- ORD record
- ord-ee3ef274294740f08d1c883d4715c28d
- Source dataset
- uspto-grants-1992_06
- Patent number
- US05120747
Reaction notes
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