HCID 19748502, compound → 2-(1-Aminoethyl)phenol hydrochloride
Reaction equation
[ClH:1].C([O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH:16]([NH2:18])[CH3:17])C1C=CC=CC=1>[Pd].CO>[ClH:1].[OH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH:16]([NH2:18])[CH3:17]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A mixture obtained by adding 2.64 g of (+)-1-(2-benzyloxyphenyl)ethylamine hydrochloride prepared in Referential Example (3-1) and 0.26 g of 5% Pd-C to 40 ml of methanol was subjected to hydrogenation at room temperature and normal pressure, whereby 256 ml of hydrogen was absorbed. After filtering off the catalyst, the filtrate was concentrated under reduced pressure to give 1.78 g of (+)-1-(2-hydroxyphenyl)ethylamine hydrochloride.
Workup
- customA mixture obtained
- customwas subjected to hydrogenation at room temperature
- customnormal pressure, whereby 256 ml of hydrogen was absorbed
- filtrationAfter filtering off the catalyst
- concentrationthe filtrate was concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-4b107e0caab545a3820dcee34921607a
- Source dataset
- uspto-grants-1992_06
- Patent number
- US05120853
Reaction notes
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