Ammonium Chloride → HCID 15341843, compound

Reaction equation

[CH:1]1([CH2:4][C:5]2[C:6]([OH:16])=[C:7]([CH:12]=[CH:13][C:14]=2[OH:15])[C:8](OC)=[O:9])[CH2:3][CH2:2]1.[Cl-].[NH4+:18]>>[CH:1]1([CH2:4][C:5]2[C:6]([OH:16])=[C:7]([CH:12]=[CH:13][C:14]=2[OH:15])[C:8]([NH2:18])=[O:9])[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 25517Ammonium Chloride

HCID 15341799HCID 15341799, compound

Product 1

HCID 15341843HCID 15341843, compound

Procedure

The compound of Example 15 is heated at 50° C. in a saturated ammonium chloride solution overnight. The reaction mixture is thoroughly extracted with ethyl acetate, and the solvent dried (Na2SO4) and evaporated in vacuo to afford the crude product. Chromatographic purification or silica gel using ethyl acetate/hexane (4:6) as eluant affords the product.

Workup

extractionThe reaction mixture is thoroughly extracted with ethyl acetate
dry with materialthe solvent dried (Na2SO4)
customevaporated in vacuo

Sources & evidence

ORD record: ord-71a48cbf662e413eadfd439cf6f36b22
Source dataset: uspto-grants-1992_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05124350

Reaction notes

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