Acetate → 4-Fluoro-2-methoxy-5-morpholin-4-yl-benzoic acid methyl ester

Reaction equation

[C:1](=[O:2])([O-:3])[O-:4].[C:34]([O-:35])(=[O:36])[CH3:37].[C:39]([O-:40])(=[O:41])[CH3:42].[CH2:21]1[CH2:22][O:23][CH2:24][CH2:25][NH:26]1.[CH3:27][c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1.[CH3:7][O:8][C:9]([c:10]1[c:11]([O:18][CH3:19])[cH:12][c:13]([F:17])[c:14]([Br:16])[cH:15]1)=[O:20].[Cs+:5].[Cs+:6].[Pd+2:38]>>[CH3:7][O:8][C:9]([c:10]1[c:11]([O:18][CH3:19])[cH:12][c:13]([F:17])[c:14]([N:26]2[CH2:21][CH2:22][O:23][CH2:24][CH2:25]2)[cH:15]1)=[O:20]

Participants

Reactant 7

HCID 175Acetate2×

HCID 1140Toluene

HCID 8083Morpholine

HCID 19660Carbonate Ion

HCID 104967Cesium cation2×

HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)

HCID 22093493Methyl 5-bromo-4-fluoro-2-methoxybenzoate

Product 1

Sources & evidence

ORD record: ord-2adcf43b31a64bd28174071d45856ef8
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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