Thionyl Chloride → Chromone-3-carbonyl chloride

HRID 895011

Reaction equation

[O:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[C:3]([C:12]([OH:14])=O)=[CH:2]1.S(Cl)([Cl:17])=O>>[O:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[C:3]([C:12]([Cl:17])=[O:14])=[CH:2]1

Participants

Reactant 2

HCID 24386Thionyl Chloride

HCID 181620Chromone-3-carboxylic acid

Product 1

HCID 15041156Chromone-3-carbonyl chlorideYield 90%

Procedure

In accordance with the procedure described in Example 5-a), chromone-3-carboxylic acid (3.8 g, 20 mmol) was treated with thionyl chloride (1.73 ml) to obtain the desired compound (3.76 g, 90%).

Sources & evidence

ORD record: ord-db0ad5a7500e43c18f7f0cc5176626b5
Source dataset: uspto-grants-1981_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04285941

Linked notes

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