1,4-Dioxane → HCID 22380705, compound

Reaction equation

[CH2:1]([N:3]([CH2:25][CH3:26])[C:4]([C:6]1[CH:24]=[CH:23][C:9]([CH2:10][C:11]2[CH:22]=[CH:21][CH:20]=[CH:19][C:12]=2[O:13]CC(O)CO)=[CH:8][CH:7]=1)=[O:5])[CH3:2].I([O-])(=O)(=O)=O.[Na+].[O:33]1CCO[CH2:35][CH2:34]1>O>[CH2:25]([N:3]([CH2:1][CH3:2])[C:4]([C:6]1[CH:24]=[CH:23][C:9]([CH2:10][C:11]2[CH:22]=[CH:21][CH:20]=[CH:19][C:12]=2[O:13][C:34](=[O:33])[CH3:35])=[CH:8][CH:7]=1)=[O:5])[CH3:26]

Participants

Procedure

1-[2-(4-Diethylcarbamoylbenzyl)phenoxy]-2,3-dihydroxypropane (263 mg) was dissolved in a mixed solution of dioxane (2.6 ml) and water (2.6 ml), added with sodium periodate (362 mg) and stirred at room temperature for 1 hour. The reaction mixture was added with water (10 ml) and extracted twice with dichloromethane (10 ml). The organic layer was dried over anhydrous magnesium sulfate, and then the solvent was evaporated under reduced pressure to obtain 239 mg of the title compound. Yield: 100%.