HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 1-Benzyl-4-phenylpiperidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 1-Benzyl-4-cyano-4-phenylpiperidine | HCID 191408 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-Benzyl-4-phenylpiperidine-4-carboxamide | HCID 96423 | — |
Reaction Steps
(a′) 1-benzyl-4-cyano-4-phenylpiperidine, prepared in situ via neutralization of its hydrochloride, is treated with 94-96% sulfuric acid and acetic acid in toluene at 80-100° C. and the 1-benzyl-4-phenyl-4-piperidinecarboxamide thus obtained is treated with bromine in the presence of sodium methoxide; and then
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06916929B2 |
| Source dataset | uspto-grants-2005_07 |
| ORD ID | ord-724d21cdd37c4afd8037ad128005f9e1 |
| Source note | uspto-grants-2005_07 |