Sodium Methoxide → 3-cyclopropyl-1H-quinazoline-2,4-dione
Reaction equation
C[O:2][C:3](=O)[NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11](=[O:16])[NH:12][CH:13]1[CH2:15][CH2:14]1.C[O-].[Na+]>CO>[CH:13]1([N:12]2[C:11](=[O:16])[C:6]3[C:5](=[CH:10][CH:9]=[CH:8][CH:7]=3)[NH:4][C:3]2=[O:2])[CH2:15][CH2:14]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of (2-cyclopropylcarbamoyl-phenyl)-carbamic acid methyl ester was dissolved in MeOH (100 ml) and treated with NaOMe (0.5 M, 5 ml, 2.5 mmol) and the mixture heated to reflux for 12 h. The mixture was cooled and filtered to give 4.05 g (53%) of 3-cyclopropyl-1H-quinazoline-2,4-dione as a white solid.
Workup
- temperaturethe mixture heated
- temperatureto reflux for 12 h
- temperatureThe mixture was cooled
- filtrationfiltered
Sources & evidence
- ORD record
- ord-3790d333a5eb4b9c9f33ac2782c1edb4
- Source dataset
- uspto-grants-2005_07
- Patent number
- US06919331B2
Reaction notes
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