Bromine → 7-Bromomethyl-8-propyl-[1,2,4]triazolo[1,5-c]pyrimidine
Reaction equation
[Br:1]Br.[CH3:3][C:4]1[N:9]=[CH:8][N:7]2[N:10]=[CH:11][N:12]=[C:6]2[C:5]=1[CH2:13][CH2:14][CH3:15]>CC(O)=O>[Br:1][CH2:3][C:4]1[N:9]=[CH:8][N:7]2[N:10]=[CH:11][N:12]=[C:6]2[C:5]=1[CH2:13][CH2:14][CH3:15]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
Br2 (0.153 ml, 3 mmol) is added dropwise to a solution of 7-methyl-8-propyl-[1,2,4]triazolo[1,5-c]pyrimidine (3 mmol) heated at 100° C. in HOAc (10 ml). After the addition, the mixture is stirred at 100° C. overnight. The solvent is removed in vacuo and the residue dissolved in EtOAc (15 ml), washed with Na2S2O3 solution (sat. 5 ml), followed by NaHCO3 (10 ml), and brine (10 ml). The organic phase is dried (Na2SO4) and evaporated. The resulting yellow oil is purified by PTLC, which provides the title compound.