Water → Perindopril erbumine monohydrate

HRID 898742Notes

Reaction equation

HRID 898742 reaction equation
[CH3:1][CH2:2][CH2:3][C@H:4]([NH:10][C@H:11]([C:13]([N:15]1[C@H:23]([C:24]([OH:26])=[O:25])[CH2:22][C@H:21]2[C@@H:16]1[CH2:17][CH2:18][CH2:19][CH2:20]2)=[O:14])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH3:27][C:28]([NH2:31])([CH3:30])[CH3:29].[OH2:32]>C(#N)C>[CH3:1][CH2:2][CH2:3][C@H:4]([NH:10][C@H:11]([C:13]([N:15]1[C@H:23]([C:24]([OH:26])=[O:25])[CH2:22][C@H:21]2[C@@H:16]1[CH2:17][CH2:18][CH2:19][CH2:20]2)=[O:14])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH3:27][C:28]([NH2:31])([CH3:30])[CH3:29].[OH2:32]

Participants

4

Reactant 2

HCID 962WaterHCID 441313Perindopril Erbumine

Product 1

HCID 9847044Perindopril erbumine monohydrate

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Perindopril erbumine (5 gms) was suspended in acetonitrile (75 ml). To this was added water (0.4 ml) and the contents heated to dissolve the solids and cooled to 0 EC. The resulting slurry was filtered to obtain perindopril erbumine monohydrate (2.9 gms).

Workup

  1. temperaturethe contents heated
  2. dissolutionto dissolve the solids
  3. temperaturecooled to 0 EC
  4. filtrationThe resulting slurry was filtered

Sources & evidence

ORD record
ord-5a42d62a17dd43a8b107ff4b4ae0b469
Source dataset
uspto-grants-2008_04
Patent number
US07351840B2

Reaction notes

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