1-Methylindole → 3-[(2-Methoxyphenyl)-pyrrolidin-1-yl-methyl]-1-methyl-1H-indole

HRID 9000

Reaction equation

[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3]1.[Cl-].[CH3:12][O:13][C:14]1[CH:25]=[CH:24][CH:23]=[CH:22][C:15]=1[CH:16]=[N+:17]1[CH2:21][CH2:20][CH2:19][CH2:18]1>>[CH3:12][O:13][C:14]1[CH:25]=[CH:24][CH:23]=[CH:22][C:15]=1[CH:16]([N:17]1[CH2:21][CH2:20][CH2:19][CH2:18]1)[C:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[N:2]([CH3:1])[CH:3]=1

Participants

Reactant 2

HCID 117811-Methylindole

HCID 179122531-(2-Methoxy-benzylidene)pyrrolidinium chloride

Product 1

HCID 99668573-[(2-Methoxyphenyl)-pyrrolidin-1-yl-methyl]-1-methyl-1H-indole

Procedure

The preparation was carried out in accordance with general synthesis instructions 4 from 1-methyl-1H-indole and 1-(2-methoxy-benzylidene)-pyrrolidinium chloride.

Sources & evidence

ORD record: ord-211178e8e66b40dc95d56af13d564324
Source dataset: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07091220B2

Linked notes

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