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2-Chloro-N,N-dimethylethylamine → 3-[(Aminocarbonyl)amino]-5-{3-[2-(dimethylamino)ethoxy]phenyl}-2-thiophenecarboxamide

HRID 900428
Notes
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Reaction equation

HRID 900428 reaction equation
[NH2:1][C:2]([NH:4][C:5]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([OH:16])[CH:11]=2)[S:7][C:6]=1[C:17]([NH2:19])=[O:18])=[O:3].Cl[CH2:21][CH2:22][N:23]([CH3:25])[CH3:24]>>[NH2:1][C:2]([NH:4][C:5]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([O:16][CH2:21][CH2:22][N:23]([CH3:25])[CH3:24])[CH:11]=2)[S:7][C:6]=1[C:17]([NH2:19])=[O:18])=[O:3]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

3

Reactant 2

HCID 79012-Chloro-N,N-dimethylethylamineHCID 99654243-[(Aminocarbonyl)amino]-5-(3-hydroxyphenyl)-2-thiophenecarboxamide

Product 1

HCID 101324893-[(Aminocarbonyl)amino]-5-{3-[2-(dimethylamino)ethoxy]phenyl}-2-thiophenecarboxamide

Procedure

Prepared by the method of Example 9(b) using the product of Example 6 and N-(2-chloroethyl)dimethylamine.

Workup

  1. customPrepared by the method of Example 9(b)

Sources & evidence

ORD record
ord-bdf6a3ded20f4bcd8277cfc29c2d1962
Source dataset
uspto-grants-2008_04
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07358376B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes