Acetic Anhydride → N-(3-cyanothiophen-2-yl)acetamide

HRID 900444

Reaction equation

HRID 900444 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[C:7]#[N:8].[C:9](OC(=O)C)(=[O:11])[CH3:10]>>[C:9]([NH:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[C:7]#[N:8])(=[O:11])[CH3:10]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 7366072-Aminothiophene-3-carbonitrile

Product 1

HCID 676450N-(3-cyanothiophen-2-yl)acetamide

Procedure

2-Amino-3-cyanothiophene (12 g) was heated at reflux in acetic anhydride (34 ml) for 15 minutes, cooled and refrigerated for 3 h. The crystalline product was filtered off (13.6 g).

Workup

  1. temperaturecooled
  2. filtrationThe crystalline product was filtered off (13.6 g)

Sources & evidence

ORD record
ord-253eee24c3de45a79cbb8584166f4291
Source dataset
uspto-grants-2008_04
Patent number
US07358376B2

Linked notes

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