Diethyl Ether → 4-(4-Chlorothiophen-2-yl)-1,3-thiazol-2-amine
Reaction equation
BrBr.CCOCC.[Cl:8][C:9]1[CH:10]=[C:11]([C:14](=O)[CH3:15])[S:12][CH:13]=1.[NH2:17][C:18]([NH2:20])=[S:19]>CCO>[NH2:20][C:18]1[S:19][CH:15]=[C:14]([C:11]2[S:12][CH:13]=[C:9]([Cl:8])[CH:10]=2)[N:17]=1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
Bromine was added to an ether solution of 4-chloro-2-acetylthiophene under ice cooling, and the mixture was stirred at room temperature for 2 hours to obtain a brominated compound. Thiourea was added to an EtOH solution of the brominated compound at room temperature, and the mixture was stirred overnight at 80° C. to obtain 2-amino-4-(4-chlorothiophen-2-yl)thiazole.
Workup
- customto obtain a brominated compound
- stirringthe mixture was stirred overnight at 80° C.
Sources & evidence
- ORD record
- ord-f5d94976bd19497ea4eb7126179aad9f
- Source dataset
- uspto-grants-2008_04
- Patent number
- US07361658B2
Reaction notes
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