Reaction equation
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([O:15][CH:16]1[CH2:21][CH2:20][N:19]([CH:22]([CH3:24])[CH3:23])[CH2:18][CH2:17]1)=[CH:10][CH:9]=2)=[O:5])C.C(OC(C1NC2C(C=1)=CC(O)=CC=2)=O)C.C(N1CCC(O)CC1)(C)C>>[CH:22]([N:19]1[CH2:18][CH2:17][CH:16]([O:15][C:11]2[CH:12]=[C:13]3[C:8](=[CH:9][CH:10]=2)[NH:7][C:6]([C:4]([OH:5])=[O:3])=[CH:14]3)[CH2:21][CH2:20]1)([CH3:24])[CH3:23]Participants
4
Procedure
According to the procedure described for the synthesis of Example 5/step 1 5-(1-isopropyl-piperidin-4-yloxy)-1H-indole-2-carboxylic acid ethyl ester was synthesized from 5-hydroxy-1H-indole-2-carboxylic acid ethyl ester (commercially available) and 1-isopropyl-piperidin-4-ol (commercially available). The title compound was yielded in 33% as off-white solid. MS (m/e): 331.1 (MH+, 100%).
Sources & evidence
- ORD record
- ord-3107c198f75b46f3b75c499866bceb56
- Source dataset
- uspto-grants-2008_04
- Patent number
- US07361682B2
Linked notes
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