7-Ethylindole → 7-ethyl-3-[(2-methoxyphenyl)-morpholin-4-yl-methyl]-1H-indole

HRID 9021

Reaction equation

[CH2:1]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[NH:10][CH:9]=[CH:8]2)[CH3:2].[Cl-].[CH3:13][O:14][C:15]1[CH:27]=[CH:26][CH:25]=[CH:24][C:16]=1[CH:17]=[N+:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1>>[CH2:1]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[NH:10][CH:9]=[C:8]2[CH:17]([C:16]1[CH:24]=[CH:25][CH:26]=[CH:27][C:15]=1[O:14][CH3:13])[N:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1)[CH3:2]

Participants

Reactant 2

HCID 27247117-Ethylindole

HCID 155519114-(2-Methoxy-benzylidene)-morpholin-4-ium chloride

Product 1

HCID 99030267-ethyl-3-[(2-methoxyphenyl)-morpholin-4-yl-methyl]-1H-indole

Procedure

The preparation was carried out in accordance with general synthesis instructions 4 from 7-ethyl-1H-indole and 4-(2-methoxy-benzylidene)-morpholin-4-ium chloride.

Sources & evidence

ORD record: ord-d2d145461bca48b586576fe619b29b95
Source dataset: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07091220B2

Linked notes

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