Propionic Acid → N-(2-Chloro-3-trifluoromethylbenzyl)-2-(2-methoxyphenyl)propionamide
Reaction equation
[C:1](O)(=[O:4])CC.[Cl:6][C:7]1[C:25]([C:26]([F:29])([F:28])[F:27])=[CH:24][CH:23]=[CH:22][C:8]=1[CH2:9][NH:10][C:11](=[O:21])[CH:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1Cl)[CH3:13]>>[Cl:6][C:7]1[C:25]([C:26]([F:29])([F:28])[F:27])=[CH:24][CH:23]=[CH:22][C:8]=1[CH2:9][NH:10][C:11](=[O:21])[CH:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[O:4][CH3:1])[CH3:13]Participants
3
Procedure
The titled compound was prepared from 22-methoxyphenyl)propionic acid in 42% yield in the same manner as the preparation of N-(2-Chloro-3-trifluoromethylbenzyl)-2-(2-chlorophenyl)propionamide in Example 184b. MS (ESI) 372 (MH+).
Sources & evidence
- ORD record
- ord-0975714eff3246cfbe4c077f790f32f4
- Source dataset
- uspto-grants-2008_04
- DOI