4-Methyl-2-phenylpentanoic acid → 2-Phenyl-4-methylpentanoic acid amide

HRID 902747Notes

Reaction equation

HRID 902747 reaction equation
[C:1]1([CH:7]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:8](O)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.COC1C=CC(C(C)C([NH2:26])=O)=CC=1>>[C:1]1([CH:7]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:8]([NH2:26])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 2365774-Methyl-2-phenylpentanoic acidHCID 202698892-(4-Methoxyphenyl)propionamide

Product 1

HCID 3162092-Phenyl-4-methylpentanoic acid amideYield 94%

Procedure

The titled compound was prepared from 2-phenyl-4-methylpentanoic acid in 94% yield in the same manner as the preparation of 2-(4-Methoxyphenyl)propionamide in Example 188b. MS (ESI) 192 (MH+)

Sources & evidence

ORD record
ord-a0041e20a4aa4bcf9160c14a18773239
Source dataset
uspto-grants-2008_04
Patent number
US07365085B2

Reaction notes

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