Methyl Isocyanate → HCID 13420167, compound
Reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:13]=[CH:12][CH:11]=[CH:10][C:4]=1[O:5][CH:6]1[CH2:9][NH:8][CH2:7]1.[CH3:16][N:17]=[C:18]=[O:19]>C1C=CC=CC=1>[CH3:16][NH:17][C:18]([N:8]1[CH2:9][CH:6]([O:5][C:4]2[CH:10]=[CH:11][CH:12]=[CH:13][C:3]=2[C:2]([F:1])([F:14])[F:15])[CH2:7]1)=[O:19]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a stirring solution of 3-(2-trifluoromethylphenoxy) azetidine (4.5 g., 0.02 mole) in 50 ml. of dry benzene was added slowly at room temperature 1.2 g. (0.02 mole) of methylisocyanate. After an additional 30 minutes a solid separated which was collected and recrystallized from benzene. The product (3.5 g., 68%) melted at 134°-136° C.
Workup
- customAfter an additional 30 minutes a solid separated which
- customwas collected
- customrecrystallized from benzene
Sources & evidence
- ORD record
- ord-6ab3cd699c274f039b258f156f05e8aa
- Source dataset
- uspto-grants-1980_10
- Patent number
- US04226861
Reaction notes
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