L-Glutamine, N2-((1,1-dimethylethoxy)carbonyl)- → L-Glutamine

Reaction equation

C(N[C@H](C(O)=O)CCCCN)(OC(C)(C)C)=O.C([NH:25][C@H:26]([C:32]([OH:34])=[O:33])[CH2:27][CH2:28][C:29](=[O:31])[NH2:30])(OC(C)(C)C)=O>>[NH2:25][C@H:26]([C:32]([OH:34])=[O:33])[CH2:27][CH2:28][C:29](=[O:31])[NH2:30]

Participants

Reactant 2

HCID 83687L-Glutamine, N2-((1,1-dimethylethoxy)carbonyl)-

HCID 2733284epsilon-tert-Butyloxycarbonyl-lysine

Product 1

HCID 5961L-Glutamine

Procedure

To the product of Step (B) above, the P-nitrophenyl ester of Boc-L-Glutamine [Gln (ONp), Peninsula, supra.] is coupled following the procedure of Step (E), Example 1, supra.

Sources & evidence

ORD record: ord-4a4b87a948be4bf6a40f5bdf235696cd
Source dataset: uspto-grants-1980_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04230696

Reaction notes

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