4-(2-Chloroethyl)morpholine → HCID 23334054, compound
Reaction equation
[C:1]1([C:7]2[C:8](=[O:20])[O:9][C:10]3[C:15]([C:16]=2[OH:17])=[CH:14][CH:13]=[C:12]([O:18][CH3:19])[CH:11]=3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[O:21]1[CH2:26][CH2:25][N:24]([CH2:27][CH2:28]Cl)[CH2:23][CH2:22]1>>[CH3:19][O:18][C:12]1[CH:11]=[C:10]2[C:15]([C:16]([O:17][CH2:28][CH2:27][N:24]3[CH2:25][CH2:26][O:21][CH2:22][CH2:23]3)=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[C:8](=[O:20])[O:9]2)=[CH:14][CH:13]=1Participants
3
Procedure
This compound is prepared according to the method described in Example 8 from 24.2 g. (0.09 mol) of 3-phenyl-4-hydroxy-7-methoxy-coumarin and 17.5 g. (0.117 mol) of 2-morpholino-1-chlorethane. After recrystallisation from a mixture of diisopropyl ether and ethyl acetate (70-30), 24.3 g. of a white solid are obtained. M.P. 95°-96° C.; yield 70.8% (theoretical yield 34.3 g.).
Workup
- customThis compound is prepared
- customAfter recrystallisation
- additionfrom a mixture of diisopropyl ether and ethyl acetate (70-30), 24.3 g