HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 2-Pyrrolidinone, 1-acetyl-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 2-Pyrrolidone | HCID 12025 | — |
| Product | 2-Pyrrolidinone, 1-acetyl- | HCID 70266 | 96% |
Reaction Steps
A mixture of 112 g of 2-pyrrolidinone (9) and 249 mL of acetic anhydride was heated at reflux for 2 hours. The resultant mixture was allowed to cool to room temperature, was concentrated in vacuo, and was distilled (0.8 mm Hg, 68° C.) to provide 160 g of N-acetyl-2-pyrrolidinone (4) in 96% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08012969B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-8d502b49ae6b464793197a75442691c1 |
| Source note | uspto-grants-2011_09 |