Dimethylamine → [(7-Ethyl-1H-indol-3-yl)-o-tolyl-methyl]-dimethyl-amine

HRID 9067

Reaction equation

[CH2:1]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[NH:10][CH:9]=[CH:8]2)[CH3:2].[Cl-].[CH3:13][C:14]1[CH:23]=[CH:22][CH:21]=[CH:20][C:15]=1[CH:16]=[N+:17]([CH3:19])[CH3:18].CC1C=CC=CC=1C=O.CNC>>[CH2:1]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[NH:10][CH:9]=[C:8]2[CH:16]([N:17]([CH3:18])[CH3:19])[C:15]1[CH:20]=[CH:21][CH:22]=[CH:23][C:14]=1[CH3:13])[CH3:2]

Participants

Reactant 4

HCID 674Dimethylamine

HCID 107222-Methylbenzaldehyde

HCID 27247117-Ethylindole

HCID 21985341(2-Methyl-benzylidene)-dimethylammonium chloride

Product 1

HCID 21985309[(7-Ethyl-1H-indol-3-yl)-o-tolyl-methyl]-dimethyl-amine

Procedure

The preparation was carried out in accordance with general synthesis instructions 4 from 7-ethyl-1H-indole and (2-methyl-benzylidene)-dimethylammonium chloride, which had been prepared in accordance with example 44 from 2-methyl-benzaldehyde and dimethylamine.

Sources & evidence

ORD record: ord-867d92e2aac34594979eadeda21ac344
Source dataset: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07091220B2

Linked notes

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