3-[(5-Hydroxymethyl-furan-2-ylmethyl)-amino]-phthalic acid dimethyl ester → 3-[(5-Hydroxymethyl-furan-2-ylmethyl)-amino]-phthalic acid

HRID 906790

Reaction equation

HRID 906790 reaction equation
C[O:2][C:3](=[O:23])[C:4]1[C:5](=[C:10]([NH:14][CH2:15][C:16]2[O:17][C:18]([CH2:21][OH:22])=[CH:19][CH:20]=2)[CH:11]=[CH:12][CH:13]=1)[C:6]([O:8]C)=[O:7].COCCNC1C=CC=C(C(O)=O)C=1C(O)=O>>[OH:22][CH2:21][C:18]1[O:17][C:16]([CH2:15][NH:14][C:10]2[CH:11]=[CH:12][CH:13]=[C:4]([C:3]([OH:23])=[O:2])[C:5]=2[C:6]([OH:8])=[O:7])=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 210401373-[(5-Hydroxymethyl-furan-2-ylmethyl)-amino]-phthalic acid dimethyl esterHCID 219885193-(2-Methoxy-ethylamino)-phthalic acid

Product 1

HCID 219885843-[(5-Hydroxymethyl-furan-2-ylmethyl)-amino]-phthalic acid

Procedure

3-[(5-Hydroxymethyl-furan-2-ylmethyl)-amino]-phthalic acid dimethyl ester (0.97 g, 3.04 mmol) was treated in the same manner as described above for the synthesis of 3-(2-methoxy-ethylamino)-phthalic acid. The product of the reaction, which contained a mixture of diacid and monomethyl esters, was used without further purification.

Workup

  1. customThe product of the reaction, which
  2. customwas used without further purification

Sources & evidence

ORD record
ord-d0056527f8e5498fa549493f472d9a41
Source dataset
uspto-grants-2011_09
Patent number
US08012997B2

Linked notes

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