Reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH2:8][NH:9][C:10]2[CH:18]=[CH:17][CH:16]=[C:12]([C:13]([OH:15])=O)[C:11]=2[C:19]([OH:21])=O)[O:5][C:6]=1[CH3:7].[O:22]=[C:23]1[CH:28]([N:29]2C(=O)C3C(=CC=CC=3NCCOC)C2=O)[CH2:27][CH2:26][C:25](=[O:45])[NH:24]1>>[CH3:1][C:2]1[CH:3]=[C:4]([CH2:8][NH:9][C:10]2[CH:18]=[CH:17][CH:16]=[C:12]3[C:11]=2[C:19](=[O:21])[N:29]([CH:28]2[CH2:27][CH2:26][C:25](=[O:45])[NH:24][C:23]2=[O:22])[C:13]3=[O:15])[O:5][C:6]=1[CH3:7]Participants
Procedure
3-[(4,5-Dimethyl-furan-2-ylmethyl)-amino]-phthalic acid (3 mmol) was treated in the same manner as described above for the synthesis of 2-(2,6-dioxo-piperidin-3-yl)-4-(2-methoxy-ethylamino)-isoindole-1,3-dione. The solid yellow residue was purified by preparative HPLC (Symmetry C18, isocratic, 40% acetonitrile/water) to give 0.25 g (22%) of product as a yellow solid: mp 127-129° C.; 1H NMR (DMSO-d6) δ 11.10 (s, 1H), 7.58 (dd, J=7.4 Hz and 8.4 Hz, 1H), 7.17 (d, J=8.6 Hz, 1H), 7.06 (d, J=7.1 Hz, 1H), 6.91 (t, J=6.1 Hz, 1H), 5.11 (s, 1H), 5.06 (dd, J=5.4 and 12.5 Hz, 1H), 4.45 (d, J=6.0 Hz, 2H), 2.97-2.82 (m, 1H), 2.63-2.44 (m, 2H), 2.13 (s, 3H), 2.08-1.99 (m, 1H), 1.85 (s, 3H); 13C NMR (DMSO-d6) δ 172.75, 170.02, 168.77, 167.21, 148.75, 146.18, 145.82, 136.05, 132.07, 117.57, 114.16, 110.94, 110.55, 109.61, 48.56, 38.94, 30.95, 22.10, 11.08, 9.50; Anal. Calcd. For C20H19N3O5: C, 62.99; H, 5.02; N, 11.02. Found: C, 62.75; H, 4.97; N, 10.72.
Workup
- customThe solid yellow residue was purified by preparative HPLC (Symmetry C18, isocratic, 40% acetonitrile/water)
Sources & evidence
- ORD record
- ord-f4af5b491d184511806836be09cb84df
- Source dataset
- uspto-grants-2011_09
- Patent number
- US08012997B2
Linked notes
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