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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 910233Generated: October 25, 2026

Water → 5-[4-(6-Bromo-1,3-benzothiazol-2-yl)phenyl]-1,3-oxazole

https://huagongshe.com/reaction/910233

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
Reactant2-Amino-5-bromobenzene-1-thiolHCID 1209045—
Reactant4-(5-Oxazolyl)benzaldehydeHCID 10583346—
SolventDimethyl SulfoxideHCID 679—
Product5-[4-(6-Bromo-1,3-benzothiazol-2-yl)phenyl]-1,3-oxazoleHCID 6740528758.8%

Reaction Conditions

Temperature160 °C

Reaction Steps

2 Amino-5-bromobenzenethiol (102 mg) and 4-(1,3-oxazol-5-yl)benzaldehyde (87 mg) were dissolved in dimethylsulfoxide (1 mL), followed by stirring at 160° C. for 10 minutes. Water (10 mL) was added to the reaction mixture. The precipitated matter was recovered through filtration, and washed with methanol, to thereby yield the title compound (105 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08022075B2
Source datasetuspto-grants-2011_09
ORD IDord-0e754375d48d4d6aa7a3d6b803037183
Source noteuspto-grants-2011_09