Phenol → 3-Phenoxypyridin-2-amine

HRID 911766Notes

Reaction equation

HRID 911766 reaction equation
Br[C:2]1[C:3]([NH2:8])=[N:4][CH:5]=[CH:6][CH:7]=1.[C:9]1([OH:15])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.OC1C=CC=CC=1/C=N/O>>[O:15]([C:2]1[C:3]([NH2:8])=[N:4][CH:5]=[CH:6][CH:7]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

4

Reactant 3

HCID 996PhenolHCID 8177002-Amino-3-bromopyridineHCID 135408751Salicylaldoxime

Product 1

HCID 112176683-Phenoxypyridin-2-amine

Procedure

Prepared according to the method of Example 7 Step A, starting with bromopyridin-2-amine, phenol, and (E)-2-hydroxybenzaldehyde oxime (20.61 g, 150.3 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-8c67e389abd345d18fce825702b9dc2b
Source dataset
uspto-grants-2011_09
Patent number
US08022223B2

Reaction notes

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