HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 911921Generated: October 25, 2026
Hydrochloric Acid → 3-Amino-4-methylthiophene-2-carboxylic acid
https://huagongshe.com/reaction/911921
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 3-amino-4-methylthiophene-2-carboxylate | HCID 123584 | — |
| Product | 3-Amino-4-methylthiophene-2-carboxylic acid | HCID 14989678 | 65.2% |
Reaction Steps
Methyl 3-amino-4-methylthiophene-2-carboxylate (4.67 g, 27.3 mmol) and NaOH (2N in H2O, 68 mL, 136 mmol) were stirred at 100° C. for 1 hour. The solution was cooled to 0° C. and acidified to pH=5 with addition of concentrated HCl solution to form a precipitant. The solution was filtered and the solid was dried under vacuum to give the title compound (2.8 g, 65%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08022223B2 |
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| Source dataset | uspto-grants-2011_09 |
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| ORD ID | ord-9042f6d253264544b3cfb74521586536 |
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| Source note | uspto-grants-2011_09 |
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