1-(3,5-Dichloropyridin-4-yl)piperazine → 2-[4-(3,5-Dichloropyridin-4-yl)piperazin-1-yl]-6-methyl-1H-benzoimidazole

HRID 912778

Reaction equation

HRID 912778 reaction equation
Cl[C:2]1[NH:6][C:5]2[CH:7]=[C:8]([CH3:11])[CH:9]=[CH:10][C:4]=2[N:3]=1.[Cl:12][C:13]1[CH:14]=[N:15][CH:16]=[C:17]([Cl:25])[C:18]=1[N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[Cl:12][C:13]1[CH:14]=[N:15][CH:16]=[C:17]([Cl:25])[C:18]=1[N:19]1[CH2:24][CH2:23][N:22]([C:2]2[NH:6][C:5]3[CH:7]=[C:8]([CH3:11])[CH:9]=[CH:10][C:4]=3[N:3]=2)[CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 27999841-(3,5-Dichloropyridin-4-yl)piperazineHCID 116296552-chloro-6-methyl-1H-1,3-benzodiazole

Product 1

HCID 578351202-[4-(3,5-Dichloropyridin-4-yl)piperazin-1-yl]-6-methyl-1H-benzoimidazole

Procedure

The benzoimidazole from step (b) above (0.287 g, 1.73 mmol) and 1-(3,5-dichloropyridin-4-yl)piperazine (0.4 g, 1.73 mmol, Maybridge) reacted under the conditions of Example 1d to give the title compound as a white solid. M.p. 251-254° C. MS (ESI, pos. ion) m/z: 362 (M+1).

Sources & evidence

ORD record
ord-89f4c95c294b4beebc72209b13dae09b
Source dataset
uspto-grants-2011_09
Patent number
US08026241B2

Linked notes

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