(5-Chloro-6-(piperazin-1-yl)pyridin-3-yl)methanol → HCID 178519829, compound
Reaction equation
Cl[C:2]1[NH:6][C:5]2[CH:7]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:9]=[C:10]([I:11])[C:4]=2[N:3]=1.[Cl:16][C:17]1[CH:18]=[C:19]([CH2:29][OH:30])[CH:20]=[N:21][C:22]=1[N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[Cl:16][C:17]1[CH:18]=[C:19]([CH2:29][OH:30])[CH:20]=[N:21][C:22]=1[N:23]1[CH2:28][CH2:27][N:26]([C:2]2[NH:3][C:4]3[C:10]([I:11])=[CH:9][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:7][C:5]=3[N:6]=2)[CH2:25][CH2:24]1Participants
3
Procedure
The benzoimidazole from step (c) above (69 mg, 0.2 mmol) reacted with (5-chloro-6-piperazin-1-yl-pyridin-3-yl)methanol (68 mg, 0.3 mmol, Example 60c) under the conditions of Example 3c to give the title compound as a yellow amorphous solid. MS (ESI, pos. ion) m/z: 538 (M+1).
Sources & evidence
- ORD record
- ord-74a6c5e1d00f491099ea448abafe0fa7
- Source dataset
- uspto-grants-2011_09