2-Methylpiperazine, (R)- → N-[5-Chloro-6-[(3R)-3-methyl-piperazin-1-yl]-pyridin-3-ylmethyl]-N-methyl-acetamide
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][N:10]([CH3:14])[C:11](=[O:13])[CH3:12])[CH:5]=[N:6][C:7]=1Cl.[CH3:15][C@@H:16]1[CH2:21][NH:20][CH2:19][CH2:18][NH:17]1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][N:10]([CH3:14])[C:11](=[O:13])[CH3:12])[CH:5]=[N:6][C:7]=1[N:20]1[CH2:19][CH2:18][NH:17][C@H:16]([CH3:15])[CH2:21]1Participants
3
Procedure
A mixture of N-(5,6-dichloro-pyridin-3-ylmethyl)-N-methyl-acetamide from step (a) above (233 mg, 1.0 mmol) and (R)-(−)-2-methyl-piperazine (110 mg, 1.1 mmol, Aldrich) reacted under the conditions of Example 3a to give the title compound. MS (ESI, pos. ion) m/z: 297 (M+1).
Workup
- customreacted under the conditions of Example 3a